The nature of the prinicipal type 1 interferon-producing cells in human blood

The nature of the prinicipal type 1 interferon-producing cells in human blood

Interferons (IFNs) are the most important cytokines in antiviral immune responses. "Natural IFN-producing cells" (IPCs) in human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated and further characterized because of their rarity, rapid apo...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 1999-06, Vol.284 (5421), p.1835-1837
Hauptverfasser: Siegal, Frederick P, Kadowaki, Norimitsu, Shodell, Michael, Fitzgerald-Bocarsly, Patricia A
Format: Artikel
Sprache:eng
Schlagworte:
Blood
Cells
Feedback (Response)
Immune system
Individualized Instruction
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Zusammenfassung:Interferons (IFNs) are the most important cytokines in antiviral immune responses. "Natural IFN-producing cells" (IPCs) in human blood express CD4 and major histocompatibility complex class II proteins, but have not been isolated and further characterized because of their rarity, rapid apoptosis, and lack of lineage markers.
ISSN:0036-8075
1095-9203