North- and South-Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti-HIV Activity (ChemMedChem 8/2009)

North- and South-Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti-HIV Activity (ChemMedChem 8/2009)

The inside cover picture shows the locked north (blue) and south (red) bicyclo[3.1.0]hexane nucleosides in the normal pseudorotational cycle, and the corresponding shift to a smaller cycle (nmax=7 ) caused by the insertion of a double bond. The former nucleosides are inactive, while the flattening o...

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Veröffentlicht in:ChemMedChem 2009-08, Vol.4 (8), p.1210-1210
Hauptverfasser: Russ, Pamela L, Gonzalez-Moa, Maria J, Vu, B Christie, Sigano, Dina M, Kelley, James A, Lai, Christopher C, Deschamps, Jeffrey R, Hughes, Stephen H, Marquez, Victor E
Format: Artikel
Sprache:ger
Schlagworte:
Human immunodeficiency virus
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Zusammenfassung:The inside cover picture shows the locked north (blue) and south (red) bicyclo[3.1.0]hexane nucleosides in the normal pseudorotational cycle, and the corresponding shift to a smaller cycle (nmax=7 ) caused by the insertion of a double bond. The former nucleosides are inactive, while the flattening of the embedded cyclopentene ring provides active compounds against HOS cells infected with HIV. For more details, see the Full Paper by V. E. Marquez et al. on p. 1354 ff.
ISSN:1860-7179
DOI:10.1002/cmdc.200990036