Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy

T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of reproductive immunology (1989) 2010-06, Vol.63 (6), p.601-610
Hauptverfasser:	Saito, Shigeru, Nakashima, Akitoshi, Shima, Tomoko, Ito, Mika
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - metabolism Female Humans Interleukin-17 - metabolism Male Mice Mice, Inbred BALB C Mice, Inbred DBA Pregnancy Pregnancy Complications - etiology Pregnancy Complications - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Th2 Cells - immunology Th2 Cells - metabolism Transforming Growth Factor beta - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	T-helper (Th) cells play a central role in modulating immune responses. The Th1/Th2 paradigm has now developed into the new Th1/Th2/Th17 paradigm. In addition to effector cells, Th cells are regulated by regulatory T (Treg) cells. Their capacity to produce cytokines is suppressed by immunoregulatory cytokines such as transforming growth factor (TGF)-beta and interleukin (IL)-10 or by cell-to-cell interaction. Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms.
ISSN:	1046-7408 1600-0897
DOI:	10.1111/j.1600-0897.2010.00852.x