The Nuclear Receptor Superfamily and Drug Discovery

The Nuclear Receptor Superfamily and Drug Discovery

Targeting the nuclear receptors: The ligand‐binding domain of the glucocorticoid receptor (ribbon) bound with the ligand, dexamethasone (space‐filling) is just one of the many pictures that are becoming clearer in the field of nuclear receptor (NR) research. Recent developments in drug discovery sho...

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Veröffentlicht in:ChemMedChem 2006-05, Vol.1 (5), p.504-523
Hauptverfasser: Moore, John T., Collins, Jon L., Pearce, Kenneth H.
Format: Artikel
Sprache:eng
Schlagworte:
Drug Design
gene expression
inhibitors
Ligands
medicinal chemistry
Models, Molecular
receptors
Receptors, Cytoplasmic and Nuclear - physiology
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Zusammenfassung:Targeting the nuclear receptors: The ligand‐binding domain of the glucocorticoid receptor (ribbon) bound with the ligand, dexamethasone (space‐filling) is just one of the many pictures that are becoming clearer in the field of nuclear receptor (NR) research. Recent developments in drug discovery show great promise for the treatment of many NR‐related diseases.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.200600006