Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

Potential appetite control: A straightforward parallel solution‐phase synthesis of novel thiazole derivatives with varying linker moieties gave access to a set of compounds 1. Assessments of artificial membrane permeability and solubility show that some members of this compound class may be suitable...

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Veröffentlicht in:	ChemMedChem 2006-01, Vol.1 (1), p.45-48
Hauptverfasser:	Nettekoven, Matthias, Guba, Wolfgang, Neidhart, Werner, Mattei, Patrizio, Pflieger, Philippe, Plancher, Jean-Marc, Taylor, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	combinatorial chemistry Free-Wilson analysis heterocycles Ligands neuropeptide Y5 Receptors, Neuropeptide Y - drug effects structure-activity relationships Thiazoles - chemistry Thiazoles - pharmacology
Online-Zugang:	Volltext
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