Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties

Potential appetite control: A straightforward parallel solution‐phase synthesis of novel thiazole derivatives with varying linker moieties gave access to a set of compounds 1. Assessments of artificial membrane permeability and solubility show that some members of this compound class may be suitable antagonists for the neuropeptide Y5 receptor, which is involved in the stimulation of food intake.