Enzymatic synthesis and antioxidant properties of L-ascorbyl oleate and L-ascorbyl linoleate

L-Ascorbyl oleate and L-ascorbyl linoleate were synthesized by an immobilized lipase from Candida antarctica with yields of 38% and 44%, respectively. L-Ascorbyl oleate was stable in sterile culture medium over 12 h at 37 degrees C but L-ascorbyl linoleate degraded by 17%. Ascorbyl oleate had a bett...

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Veröffentlicht in:	Biotechnology letters 2004-12, Vol.26 (23), p.1777-1780
Hauptverfasser:	Song, Q.X, Wei, D.Z, Zhou, W.Y, Xu, W.Q, Yang, S.L
Format:	Artikel
Sprache:	eng
Schlagworte:	antioxidant activity Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Ascorbic Acid - analogs & derivatives Ascorbic Acid - chemical synthesis Ascorbic Acid - chemistry Ascorbic Acid - pharmacology ascorbic acids Biological and medical sciences Biotechnology Candida antarctica Cell culture cell lines Cell Survival - drug effects Cells, Cultured Chemical synthesis Dose-Response Relationship, Drug Drug Stability Endothelial cells Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Enzymatic synthesis Enzymes Enzymes, Immobilized - chemistry Esterification fatty acid esters Fundamental and applied biological sciences. Psychology Humans Hydrogen peroxide Hydrogen Peroxide - pharmacology Immobilized enzymes Kinetics L-ascorbic acid derivatives Linoleic acid Linoleic Acids - chemical synthesis Linoleic Acids - pharmacology Lipase - chemistry Oleic acid Oleic Acid - chemical synthesis Oleic Acid - pharmacology Oleic Acids Oxidative Stress - drug effects Q1 Q2 Reactive Oxygen Species - metabolism synthesis Triacylglycerol lipase
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Zusammenfassung:	L-Ascorbyl oleate and L-ascorbyl linoleate were synthesized by an immobilized lipase from Candida antarctica with yields of 38% and 44%, respectively. L-Ascorbyl oleate was stable in sterile culture medium over 12 h at 37 degrees C but L-ascorbyl linoleate degraded by 17%. Ascorbyl oleate had a better protective effect on human umbilical cord vein endothelial cells treated with H2O2 than of L-ascorbic acid-2-phosphate-6-palmitate (Asc2P6P).
ISSN:	0141-5492 1573-6776
DOI:	10.1007/s10529-004-4607-8