Synthesis of Substituted 2-Aminopyrrole Analogs of Lidocaine I

The synthesis, local anesthetic, and antiarrhythmic properties of nine 2-diethylaminoacetamido-3-cyano-4-methyl-5-substituted pyrroles are described. All compounds showed local anesthetic activity by the guinea pig wheal test and antiarrhythmic activity for chloroform-induced ventricular arrhythmias...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1979-03, Vol.68 (3), p.317-320
Hauptverfasser:	Johnson, Ronald W., Keenan, Thomas H., Kosh, Joseph W., Walter Sowell, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopyrrole analogs of lidocaine 2-Aminopyrrole analogs of lidocaine various—synthesized, evaluated for local anesthetic activity in guinea pigs and antiarrhythmic activity in mice Anesthetics, Local - chemical synthesis Animals Anti-Arrhythmia Agents - chemical synthesis evaluated for local anesthetic activity in guinea pigs and antiarrhythmic activity in mice Guinea Pigs Lidocaine - analogs & derivatives Lidocaine - chemical synthesis Lidocaine - pharmacology Lidocaine analogs-2-aminopyrroles synthesized Methods Mice Pyrroles - chemical synthesis Pyrroles - pharmacology Structure-activity relationships-various 2-aminopyrrole analogs of lidocaine evaluated for local anesthetic activity in guinea pigs and antiarrhythmic activity in mice various-synthesized
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Beschreibung
Zusammenfassung:	The synthesis, local anesthetic, and antiarrhythmic properties of nine 2-diethylaminoacetamido-3-cyano-4-methyl-5-substituted pyrroles are described. All compounds showed local anesthetic activity by the guinea pig wheal test and antiarrhythmic activity for chloroform-induced ventricular arrhythmias in mice.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600680316