A Lipid Anticoagulant from Brain Tissue. Physiochemical Characteristics and Action in vitro and in vivo
Summary A heat labile lipid inhibitor of blood coagulation has been extracted from brain tissue, differing in potency and other respects from similar known anticoagulants. It has a pronounced antithromboplastic activity especially against homologous brain extracts in homologous plasma. Though the an...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1948-05, Vol.68 (1), p.110-117 |
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| container_end_page | 117 |
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| container_issue | 1 |
| container_start_page | 110 |
| container_title | Experimental biology and medicine (Maywood, N.J.) |
| container_volume | 68 |
| creator | Tocantins, Leandro M. Carroll, Robert T. McBride, Thomas J. |
| description | Summary
A heat labile lipid inhibitor of blood coagulation has been extracted from brain tissue, differing in potency and other respects from similar known anticoagulants. It has a pronounced antithromboplastic activity especially against homologous brain extracts in homologous plasma. Though the anticoagulant power of this lipid antithrombo-plastin in vitro is still less than that of heparin, it has a more lasting effect when injected intravenously than a solution of heparin of equivalent potency. |
| doi_str_mv | 10.3181/00379727-68-16408 |
| format | Article |
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A heat labile lipid inhibitor of blood coagulation has been extracted from brain tissue, differing in potency and other respects from similar known anticoagulants. It has a pronounced antithromboplastic activity especially against homologous brain extracts in homologous plasma. Though the anticoagulant power of this lipid antithrombo-plastin in vitro is still less than that of heparin, it has a more lasting effect when injected intravenously than a solution of heparin of equivalent potency.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-68-16408</identifier><identifier>PMID: 18863692</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Anticoagulants ; Blood Coagulation ; Brain ; In Vitro Techniques ; Lipids ; Old Medline</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1948-05, Vol.68 (1), p.110-117</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c253t-6f8dede6d1d3edab69e744882f2b1947cb4b36261a5af00440997ba1c21209e03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18863692$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tocantins, Leandro M.</creatorcontrib><creatorcontrib>Carroll, Robert T.</creatorcontrib><creatorcontrib>McBride, Thomas J.</creatorcontrib><title>A Lipid Anticoagulant from Brain Tissue. Physiochemical Characteristics and Action in vitro and in vivo</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Summary
A heat labile lipid inhibitor of blood coagulation has been extracted from brain tissue, differing in potency and other respects from similar known anticoagulants. It has a pronounced antithromboplastic activity especially against homologous brain extracts in homologous plasma. Though the anticoagulant power of this lipid antithrombo-plastin in vitro is still less than that of heparin, it has a more lasting effect when injected intravenously than a solution of heparin of equivalent potency.</description><subject>Anticoagulants</subject><subject>Blood Coagulation</subject><subject>Brain</subject><subject>In Vitro Techniques</subject><subject>Lipids</subject><subject>Old Medline</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1948</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMlOwzAURS0EoqXwAWyQV-xSPCQelqVikirBoqwtx3FaV0lc7ASpf487IHasnvx87pHeBeAWoynFAj8gRLnkhGdMZJjlSJyBMS5okVEm5TkY7_-zPTACVzFuEMIFJ-wSjLAQLDFkDFYzuHBbV8FZ1zvj9WpodNfDOvgWPgbtOrh0MQ52Cj_Wu-i8WdvWGd3A-VoHbXobXEzBCHWXHKZ3voMp9O364A-7w-PbX4OLWjfR3pzmBHw-Py3nr9ni_eVtPltkhhS0z1gtKltZVuGK2kqXTFqe50KQmpRY5tyUeUkZYVgXukYoz5GUvNTYEEyQtIhOwP3Ruw3-a7CxV62LxjbpKuuHqJKt4JjLBOIjaIKPMdhabYNrddgpjNS-XfXbrmJCHdpNmbuTfChbW_0lTnUmYHoEol5ZtfFD6NKx_xh_AGr8gts</recordid><startdate>194805</startdate><enddate>194805</enddate><creator>Tocantins, Leandro M.</creator><creator>Carroll, Robert T.</creator><creator>McBride, Thomas J.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>194805</creationdate><title>A Lipid Anticoagulant from Brain Tissue. Physiochemical Characteristics and Action in vitro and in vivo</title><author>Tocantins, Leandro M. ; Carroll, Robert T. ; McBride, Thomas J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-6f8dede6d1d3edab69e744882f2b1947cb4b36261a5af00440997ba1c21209e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1948</creationdate><topic>Anticoagulants</topic><topic>Blood Coagulation</topic><topic>Brain</topic><topic>In Vitro Techniques</topic><topic>Lipids</topic><topic>Old Medline</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tocantins, Leandro M.</creatorcontrib><creatorcontrib>Carroll, Robert T.</creatorcontrib><creatorcontrib>McBride, Thomas J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tocantins, Leandro M.</au><au>Carroll, Robert T.</au><au>McBride, Thomas J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Lipid Anticoagulant from Brain Tissue. Physiochemical Characteristics and Action in vitro and in vivo</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1948-05</date><risdate>1948</risdate><volume>68</volume><issue>1</issue><spage>110</spage><epage>117</epage><pages>110-117</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Summary
A heat labile lipid inhibitor of blood coagulation has been extracted from brain tissue, differing in potency and other respects from similar known anticoagulants. It has a pronounced antithromboplastic activity especially against homologous brain extracts in homologous plasma. Though the anticoagulant power of this lipid antithrombo-plastin in vitro is still less than that of heparin, it has a more lasting effect when injected intravenously than a solution of heparin of equivalent potency.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>18863692</pmid><doi>10.3181/00379727-68-16408</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0037-9727 |
| ispartof | Experimental biology and medicine (Maywood, N.J.), 1948-05, Vol.68 (1), p.110-117 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74457179 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Anticoagulants Blood Coagulation Brain In Vitro Techniques Lipids Old Medline |
| title | A Lipid Anticoagulant from Brain Tissue. Physiochemical Characteristics and Action in vitro and in vivo |
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