A Lipid Anticoagulant from Brain Tissue. Physiochemical Characteristics and Action in vitro and in vivo

Summary A heat labile lipid inhibitor of blood coagulation has been extracted from brain tissue, differing in potency and other respects from similar known anticoagulants. It has a pronounced antithromboplastic activity especially against homologous brain extracts in homologous plasma. Though the anticoagulant power of this lipid antithrombo-plastin in vitro is still less than that of heparin, it has a more lasting effect when injected intravenously than a solution of heparin of equivalent potency.