The origin of CSF choline and its relation to acetylcholine metabolism in brain

The origin of CSF choline and its relation to acetylcholine metabolism in brain

Elevation of serum choline levels in the rabbit either by intravenous injection of choline or by the pharmacological action of oxotremorine results in a rise in cisternal CSF choline levels. It was excluded that the oxotremorine induced rise in CSF choline levels can be ascribed to its action on the...

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Veröffentlicht in:Life sciences (1973) 1979-01, Vol.24 (3), p.231-236
Hauptverfasser: Klaver, M.M., Flentge, F., Nienhuis-Kuiper, H.E., van Praag, H.M.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine - metabolism
Animals
Atropine - pharmacology
Brain - metabolism
Choline - blood
Choline - cerebrospinal fluid
Male
Oxotremorine - pharmacology
Rabbits
Time Factors
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Zusammenfassung:Elevation of serum choline levels in the rabbit either by intravenous injection of choline or by the pharmacological action of oxotremorine results in a rise in cisternal CSF choline levels. It was excluded that the oxotremorine induced rise in CSF choline levels can be ascribed to its action on the CNS. Therefore changes in CSF choline levels can be merely the result of changes in peripheral choline stores and do not necessarily reflect changes in the cholinergic activity of the CNS. From isotopic labelling experiments the contribution of serum choline to CSF choline was found to be 42%.
ISSN:0024-3205
1879-0631
DOI:10.1016/0024-3205(79)90224-8