Potential Antineoplastics I: Substituted 3,5-Dioxo- and 3-Thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines

The synthesis of some 6-substituted 3,5-dioxo- and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines for possible antineoplastic activity is reported. The assigned structures were substantiated by IR, NMR, and mass spectral studies of representative members of the series. Four compounds were tested...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1979-02, Vol.68 (2), p.243-245
Hauptverfasser:	Ibrahim, El Sebai A., Shams El Dine, S.A., Soliman, Farid S.G., Labouta, Ibrahim M.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,4-Triazines, substituted—synthesized, antineoplastic activity evaluated in mice 4-Triazines 4-triazines evaluated for antineoplastic activity in mice 4-triazines evaluated in mice Animals antineoplastic activity evaluated in mice Antineoplastic activity-various substituted 1 Antineoplastic activity—various substituted 1,2,4-triazines evaluated in mice Antineoplastic Agents - chemical synthesis Antineoplastic Agents - therapeutic use Leukemia, Experimental - drug therapy Methods Mice Structure-activity relationships- substituted 1 Structure‐activity relationships— substituted 1,2,4‐triazines evaluated for antineoplastic activity in mice substituted-synthesized Triazines - chemical synthesis Triazines - pharmacology Triazines - therapeutic use
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Zusammenfassung:	The synthesis of some 6-substituted 3,5-dioxo- and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines for possible antineoplastic activity is reported. The assigned structures were substantiated by IR, NMR, and mass spectral studies of representative members of the series. Four compounds were tested against P-388 lymphocytic leukemia and were inactive.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600680234