The Promise of Comparative Genomics in Mammals

Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of livestock, companion animals, and additional mammal species. C...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1999-10, Vol.286 (5439), p.458-481
Hauptverfasser:	O'Brien, Stephen J., Menotti-Raymond, Marilyn, Murphy, William J., Nash, William G., Wienberg, Johannes, Stanyon, Roscoe, Copeland, Neal G., Jenkins, Nancy A., Womack, James E., Jennifer A. Marshall Graves
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal genetics Animals Animals, Domestic - genetics Base Sequence Cats Chromosome Mapping Chromosomes Coding Deoxyribonucleic acid DNA Evolution, Molecular Genes Genetic aspects Genetic mapping Genetic Markers Genetics Genome Genome, Human Genomes Genomics Humans Information Transfer Mammals Mammals - genetics Medical genetics Mutation Phylogeny Reviews Rodentia - genetics Rodents
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Beschreibung
Zusammenfassung:	Dense genetic maps of human, mouse, and rat genomes that are based on coding genes and on microsatellite and single-nucleotide polymorphism markers have been complemented by precise gene homolog alignment with moderate-resolution maps of livestock, companion animals, and additional mammal species. Comparative genetic assessment expands the utility of these maps in gene discovery, in functional genomics, and in tracking the evolutionary forces that sculpted the genome organization of modern mammalian species.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.286.5439.458