Polymersomes: Tough Vesicles Made from Diblock Copolymers
Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO$_{40}$-EE$_{37}$), is several times greater than that of typical phospholipids in natural membranes. Bo...
Gespeichert in:
Veröffentlicht in: | Science (American Association for the Advancement of Science) 1999-05, Vol.284 (5417), p.1143-1146 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Vesicles were made from amphiphilic diblock copolymers and characterized by micromanipulation. The average molecular weight of the specific polymer studied, polyethyleneoxide-polyethylethylene (EO$_{40}$-EE$_{37}$), is several times greater than that of typical phospholipids in natural membranes. Both the membrane bending and area expansion moduli of electroformed polymersomes (polymer-based liposomes) fell within the range of lipid membrane measurements, but the giant polymersomes proved to be almost an order of magnitude tougher and sustained far greater areal strain before rupture. The polymersome membrane was also at least 10 times less permeable to water than common phospholipid bilayers. The results suggest a new class of synthetic thin-shelled capsules based on block copolymer chemistry. |
---|---|
ISSN: | 0036-8075 1095-9203 |
DOI: | 10.1126/science.284.5417.1143 |