Mechanism of activation of a human oncogene
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the st...
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| Veröffentlicht in: | Nature (London) 1982-11, Vol.300 (5888), p.143-149 |
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| container_end_page | 149 |
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| container_issue | 5888 |
| container_start_page | 143 |
| container_title | Nature (London) |
| container_volume | 300 |
| creator | Tabin, Clifford J. Bradley, Scott M. Bargmann, Cornelia I. Weinberg, Robert A. Papageorge, Alex G. Scolnick, Edward M. Dhar, Ravi Lowy, Douglas R. Chang, Esther H. |
| description | The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein. |
| doi_str_mv | 10.1038/300143a0 |
| format | Article |
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Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. 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Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. 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| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1982-11, Vol.300 (5888), p.143-149 |
| issn | 0028-0836 1476-4687 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | Base Sequence Cell Line Cell Transformation, Neoplastic Cloning, Molecular DNA Restriction Enzymes - metabolism Gene Expression Regulation Humanities and Social Sciences Humans Molecular Weight multidisciplinary Mutation Neoplasm Proteins - biosynthesis Oncogenes RNA, Neoplasm - analysis Science Science (multidisciplinary) Transfection Urinary Bladder Neoplasms - genetics |
| title | Mechanism of activation of a human oncogene |
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