Mechanism of activation of a human oncogene

The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the st...

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Veröffentlicht in:	Nature (London) 1982-11, Vol.300 (5888), p.143-149
Hauptverfasser:	Tabin, Clifford J., Bradley, Scott M., Bargmann, Cornelia I., Weinberg, Robert A., Papageorge, Alex G., Scolnick, Edward M., Dhar, Ravi, Lowy, Douglas R., Chang, Esther H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Line Cell Transformation, Neoplastic Cloning, Molecular DNA Restriction Enzymes - metabolism Gene Expression Regulation Humanities and Social Sciences Humans Molecular Weight multidisciplinary Mutation Neoplasm Proteins - biosynthesis Oncogenes RNA, Neoplasm - analysis Science Science (multidisciplinary) Transfection Urinary Bladder Neoplasms - genetics
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Beschreibung
Zusammenfassung:	The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/300143a0