Regulation of adrenocortical steroidogenesis by cyclic 3′-5′-guanosine monophosphate in isolated rat adrenal cells

Cyclic 3′,5′ guanosine monophosphate (cGMP) increased in isolated rat adrenocortical cells in a dose related manner with adrenocorticotropic hormone (ACTH). These increases were closely coupled to increases in steroidogenesis (r=0.95 to 1.00) as measured by corticosterone and summed corticosterone,...

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Veröffentlicht in:	Biochemical and biophysical research communications 1978-11, Vol.85 (1), p.55-61
Hauptverfasser:	Harrington, Charles A., Fenimore, David C., Farmer, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex - drug effects Adrenal Cortex - metabolism Adrenal Cortex Hormones - biosynthesis Adrenocorticotropic Hormone - pharmacology Animals Corticosterone - biosynthesis Cyclic GMP - metabolism In Vitro Techniques Kinetics Rats
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