Regulation of adrenocortical steroidogenesis by cyclic 3′-5′-guanosine monophosphate in isolated rat adrenal cells

Regulation of adrenocortical steroidogenesis by cyclic 3′-5′-guanosine monophosphate in isolated rat adrenal cells

Cyclic 3′,5′ guanosine monophosphate (cGMP) increased in isolated rat adrenocortical cells in a dose related manner with adrenocorticotropic hormone (ACTH). These increases were closely coupled to increases in steroidogenesis (r=0.95 to 1.00) as measured by corticosterone and summed corticosterone,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochemical and biophysical research communications 1978-11, Vol.85 (1), p.55-61
Hauptverfasser: Harrington, Charles A., Fenimore, David C., Farmer, Robert W.
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal Cortex - drug effects
Adrenal Cortex - metabolism
Adrenal Cortex Hormones - biosynthesis
Adrenocorticotropic Hormone - pharmacology
Animals
Corticosterone - biosynthesis
Cyclic GMP - metabolism
In Vitro Techniques
Kinetics
Rats
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cyclic 3′,5′ guanosine monophosphate (cGMP) increased in isolated rat adrenocortical cells in a dose related manner with adrenocorticotropic hormone (ACTH). These increases were closely coupled to increases in steroidogenesis (r=0.95 to 1.00) as measured by corticosterone and summed corticosterone, progesterone, and 11-desoxycorticosterone. The data are compatible with the hypothesis that cGMP is the second messenger for ACTH.
ISSN:0006-291X
1090-2104
DOI:10.1016/S0006-291X(78)80010-2