KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M- Channel
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The blophysical properties, sensitivity to...
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| Veröffentlicht in: | Science 1998-12, Vol.282 (5395), p.1890-1893 |
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| container_issue | 5395 |
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| container_title | Science |
| container_volume | 282 |
| creator | Wang, Hong-Sheng Pan, Zongming Shi, Wenmei Brown, Barry S. Wymore, Randy S. Cohen, Ira S. Dixon, Jane E. McKinnon, David |
| description | The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The blophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current. |
| doi_str_mv | 10.1126/science.282.5395.1890 |
| format | Article |
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Membrane pores ; Cell structures and functions ; Central nervous system ; Complementary DNA ; Electric potential ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; Ganglia ; Ganglia, Sympathetic - metabolism ; Gene Expression ; Genes ; Humans ; Indoles - pharmacology ; KCNQ2 Potassium Channel ; KCNQ3 Potassium Channel ; Kinetics ; Messenger RNA ; Molecular and cellular biology ; Molecular biology ; Narcotics ; Neurons ; Neurons - drug effects ; Neurons - physiology ; Oocytes ; Patch-Clamp Techniques ; Physiological aspects ; Potassium ; Potassium - metabolism ; Potassium channels ; Potassium Channels - chemistry ; Potassium Channels - drug effects ; Potassium Channels - genetics ; Potassium Channels - metabolism ; Potassium Channels, Voltage-Gated ; Pyridines - pharmacology ; Rats ; Sympathetic ganglia ; Sympathetic Nervous System - drug effects ; Sympathetic Nervous System - physiology ; Tetraethylammonium - pharmacology ; Xenopus</subject><ispartof>Science, 1998-12, Vol.282 (5395), p.1890-1893</ispartof><rights>Copyright 1998 American Association for the Advancement of Science</rights><rights>1999 INIST-CNRS</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1998 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Dec 4, 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c744t-4e6cb8165295ec9bee99aa810298e539b1ee9e630c3666a59e2be763b24db94c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2897019$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2897019$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1623001$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9836639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Hong-Sheng</creatorcontrib><creatorcontrib>Pan, Zongming</creatorcontrib><creatorcontrib>Shi, Wenmei</creatorcontrib><creatorcontrib>Brown, Barry S.</creatorcontrib><creatorcontrib>Wymore, Randy S.</creatorcontrib><creatorcontrib>Cohen, Ira S.</creatorcontrib><creatorcontrib>Dixon, Jane E.</creatorcontrib><creatorcontrib>McKinnon, David</creatorcontrib><title>KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M- Channel</title><title>Science</title><addtitle>Science</addtitle><description>The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The blophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.</description><subject>Adult</subject><subject>Anatomy</subject><subject>Animals</subject><subject>Anthracenes - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Cell membranes. Ionic channels. Membrane pores</subject><subject>Cell structures and functions</subject><subject>Central nervous system</subject><subject>Complementary DNA</subject><subject>Electric potential</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. 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pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Cell membranes. Ionic channels. Membrane pores</topic><topic>Cell structures and functions</topic><topic>Central nervous system</topic><topic>Complementary DNA</topic><topic>Electric potential</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ganglia</topic><topic>Ganglia, Sympathetic - metabolism</topic><topic>Gene Expression</topic><topic>Genes</topic><topic>Humans</topic><topic>Indoles - pharmacology</topic><topic>KCNQ2 Potassium Channel</topic><topic>KCNQ3 Potassium Channel</topic><topic>Kinetics</topic><topic>Messenger RNA</topic><topic>Molecular and cellular biology</topic><topic>Molecular biology</topic><topic>Narcotics</topic><topic>Neurons</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Oocytes</topic><topic>Patch-Clamp Techniques</topic><topic>Physiological aspects</topic><topic>Potassium</topic><topic>Potassium - metabolism</topic><topic>Potassium channels</topic><topic>Potassium Channels - chemistry</topic><topic>Potassium Channels - drug effects</topic><topic>Potassium Channels - genetics</topic><topic>Potassium Channels - metabolism</topic><topic>Potassium Channels, Voltage-Gated</topic><topic>Pyridines - 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To date, however, the genes that encode subunits of this important channel have not been identified. The blophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>9836639</pmid><doi>10.1126/science.282.5395.1890</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science, 1998-12, Vol.282 (5395), p.1890-1893 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_743682441 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Adult Anatomy Animals Anthracenes - pharmacology Biological and medical sciences Brain - metabolism Cell membranes. Ionic channels. Membrane pores Cell structures and functions Central nervous system Complementary DNA Electric potential Electrophysiology Fundamental and applied biological sciences. Psychology Ganglia Ganglia, Sympathetic - metabolism Gene Expression Genes Humans Indoles - pharmacology KCNQ2 Potassium Channel KCNQ3 Potassium Channel Kinetics Messenger RNA Molecular and cellular biology Molecular biology Narcotics Neurons Neurons - drug effects Neurons - physiology Oocytes Patch-Clamp Techniques Physiological aspects Potassium Potassium - metabolism Potassium channels Potassium Channels - chemistry Potassium Channels - drug effects Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Voltage-Gated Pyridines - pharmacology Rats Sympathetic ganglia Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Tetraethylammonium - pharmacology Xenopus |
| title | KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M- Channel |
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