KCNQ2 and KCNQ3 Potassium Channel Subunits: Molecular Correlates of the M- Channel

The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The blophysical properties, sensitivity to...

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Veröffentlicht in:	Science 1998-12, Vol.282 (5395), p.1890-1893
Hauptverfasser:	Wang, Hong-Sheng, Pan, Zongming, Shi, Wenmei, Brown, Barry S., Wymore, Randy S., Cohen, Ira S., Dixon, Jane E., McKinnon, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anatomy Animals Anthracenes - pharmacology Biological and medical sciences Brain - metabolism Cell membranes. Ionic channels. Membrane pores Cell structures and functions Central nervous system Complementary DNA Electric potential Electrophysiology Fundamental and applied biological sciences. Psychology Ganglia Ganglia, Sympathetic - metabolism Gene Expression Genes Humans Indoles - pharmacology KCNQ2 Potassium Channel KCNQ3 Potassium Channel Kinetics Messenger RNA Molecular and cellular biology Molecular biology Narcotics Neurons Neurons - drug effects Neurons - physiology Oocytes Patch-Clamp Techniques Physiological aspects Potassium Potassium - metabolism Potassium channels Potassium Channels - chemistry Potassium Channels - drug effects Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Voltage-Gated Pyridines - pharmacology Rats Sympathetic ganglia Sympathetic Nervous System - drug effects Sympathetic Nervous System - physiology Tetraethylammonium - pharmacology Xenopus
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Beschreibung
Zusammenfassung:	The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The blophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.282.5395.1890