A Glimpse of the Holy Grail?

Researchers have successfully folded a reasonably sized protein fragment by molecular dynamics simulation into a structure that resembles the native state. The ab initio physics should be augmented with all existing experimental knowledge in order to unravel the protein-folding problem.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-10, Vol.282 (5389), p.642-643
1. Verfasser:	BERENDSEN, H. J. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Amino acid sequencing Analytical, structural and metabolic biochemistry Atoms Biological and medical sciences Computer Simulation Energy Force field Free energy Fundamental and applied biological sciences. Psychology General aspects, investigation methods Homology (Biology) Inhalants Mathematical Computing Models, Molecular Molecular biology Molecular dynamics Peptide Fragments - chemistry Perspectives Physics Protein Conformation Protein Folding Protein Structure, Secondary Proteins Sampling Thermodynamics
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Beschreibung
Zusammenfassung:	Researchers have successfully folded a reasonably sized protein fragment by molecular dynamics simulation into a structure that resembles the native state. The ab initio physics should be augmented with all existing experimental knowledge in order to unravel the protein-folding problem.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.282.5389.642