Cationic Oligofluorene-Substituted Polyhedral Oligomeric Silsesquioxane as Light-Harvesting Unimolecular Nanoparticle for Fluorescence Amplification in Cellular Imaging

A new bottom‐up strategy is used to construct water‐soluble organic/inorganic fluorescent unimolecular nanoparticles based on polyhedral oligomeric silsesquioxane (POSS) and conjugated oligoelectrolyte. Their high quantum yield, good cytocompatibility, and unique whole‐cell permeability could serve as a light‐harvesting energy donor to amplify the intracellular dye fluorescence for high‐quality biological imaging through fluorescence resonance energy transfer (see image).