Investigation into the species-specific deacylation of penta-acetyl-gitoxin

Penta-acetyl-gitoxin (PAG) shows species-specific deacylation to 16-acetyl-gitoxin (16 AG; I and III) or gitoxin (II and IV) by homogenates of liver and intestinal mucosa of man (I), rabbit (II), guinea-pig (III) and rat (IV), whereas it is degraded into tri- and tetra-acetates by homogenates of gui...

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Veröffentlicht in:	European journal of clinical pharmacology 1978-12, Vol.14 (6), p.425-430
Hauptverfasser:	Haustein, K O, Pachaly, C, Megges, R, Franke, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyldigoxins - metabolism Adult Animals Biotransformation Digoxin - analogs & derivatives Guinea Pigs Humans In Vitro Techniques Intestinal Mucosa - metabolism Isomerism Liver - metabolism Mass Spectrometry Myocardium - metabolism Rabbits Rats Species Specificity
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Zusammenfassung:	Penta-acetyl-gitoxin (PAG) shows species-specific deacylation to 16-acetyl-gitoxin (16 AG; I and III) or gitoxin (II and IV) by homogenates of liver and intestinal mucosa of man (I), rabbit (II), guinea-pig (III) and rat (IV), whereas it is degraded into tri- and tetra-acetates by homogenates of guinea-pig myocardium as well as by human blood and serum. The identity of the principal and chloroform-extractable metabolities in human urine after PAG administration with 16-AG has been demonstrated by mass spectrometry.
ISSN:	0031-6970 1432-1041
DOI:	10.1007/BF00716384