Efficient synthesis of conjugated alkynyl cycloalkenones: Pd(PPh3)4-AgOAc- catalyzed direct coupling of 1-alkynes with 3-oxocycloalkenyl triflates

Palladium—silver acetate‐catalyzed cross coupling of vinyl triflates and 1‐alkynes was investigated. This strategy offered a very straightforward and efficient method for access to conjugated alkynyl cycloalkenones from the conjugated vinyl triflates and 1‐alkynes. Moreover, the triflates derived from 1,3‐cycloalkadione needed no further purification and could be reacted immediately with 1‐alkynes to provide the conjugated alkynyl cycloalkenones in excellent overall yields. Copyright © 2009 John Wiley & Sons, Ltd. Palladium–silver acetate‐catalyzed cross coupling of vinyl triflates and 1‐alkynes was investigated. This strategy offered a very straightforward and efficient method for access to conjugated alkynyl cycloalkenones from the conjugated vinyl triflates and 1‐alkynes. Moreover, the triflates derived from 1,3‐cycloalkadione needed no further purification and could be reacted immediately with 1‐alkynes to provide the conjugated alkynyl cycloalkenones in excellent overall yields.