The voltage-gated potassium channels and their relatives

The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they se...

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Veröffentlicht in:	Nature (London) 2002-09, Vol.419 (6902), p.35-42
1. Verfasser:	Yellen, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biology Calcium - metabolism Cell membranes. Ionic channels. Membrane pores Cell structures and functions Electric Conductivity Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Ion Channel Gating Ions Ligands Membranes Models, Molecular Molecular and cellular biology multidisciplinary Neurology Pores Potassium Potassium - metabolism Potassium Channels, Voltage-Gated - chemistry Potassium Channels, Voltage-Gated - metabolism Protein Conformation Proteins review-article Science Science (multidisciplinary) Signal Transduction Sodium - metabolism Substrate Specificity
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Beschreibung
Zusammenfassung:	The voltage-gated potassium channels are the prototypical members of a family of membrane signalling proteins. These protein-based machines have pores that pass millions of ions per second across the membrane with astonishing selectivity, and their gates snap open and shut in milliseconds as they sense changes in voltage or ligand concentration. The architectural modules and functional components of these sophisticated signalling molecules are becoming clear, but some important links remain to be elucidated.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/nature00978