T Cell Death and Memory

In typical immune responses, contact with antigen causes naïve T cells to proliferate and differentiate into effector cells. After the pathogen is destroyed, most effector T cells are eliminated-thereby preserving the primary T cell repertoire-but some cells survive and form long-lived memory cells....

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2001-07, Vol.293 (5528), p.245-248
Hauptverfasser:	Sprent, Jonathan, Tough, David F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antigens Biological and medical sciences Cell Death Cell Survival Cells Cellular biology Cytokines Cytokines - physiology Feedback (Response) Fundamental and applied biological sciences. Psychology Fundamental immunology Growth Immune response Immune system Immunity Immunobiology Immunologic Memory Immunology Infection - immunology Infections Lymphocytes Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Memory Pathogens T cells T lymphocytes T-Lymphocytes - immunology Vaccination Viewpoints
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Beschreibung
Zusammenfassung:	In typical immune responses, contact with antigen causes naïve T cells to proliferate and differentiate into effector cells. After the pathogen is destroyed, most effector T cells are eliminated-thereby preserving the primary T cell repertoire-but some cells survive and form long-lived memory cells. During each stage of this process, the life or death fate of T cells is strictly regulated.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1062416