Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila

One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2007-04, Vol.316 (5824), p.597-600
Hauptverfasser: Chen, Chun-Hong, Huang, Haixia, Ward, Catherine M, Su, Jessica T, Schaeffer, Lorian V, Guo, Ming, Hay, Bruce A
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Sprache:eng
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Zusammenfassung:One proposed strategy for controlling the transmission of insect-borne pathogens uses a drive mechanism to ensure the rapid spread of transgenes conferring disease refractoriness throughout wild populations. Here, we report the creation of maternal-effect selfish genetic elements in Drosophila that drive population replacement and are resistant to recombination-mediated dissociation of drive and disease refractoriness functions. These selfish elements use microRNA-mediated silencing of a maternally expressed gene essential for embryogenesis, which is coupled with early zygotic expression of a rescuing transgene.
ISSN:0036-8075
1095-9203
1095-9203
DOI:10.1126/science.1138595