Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi

Superoxide anion production and trypanocidal action of naphthoquinones on Trypanosoma cruzi

1. O 2 − production is involved in the toxic action of naphthoquinones against Trypanosoma cruzi as is inferred from the correlation between quinone effect upon growth and the rate of O 2 − release from quinone-treated epimastigotes. 2. Mitochondrial membranes contribute to O 2 − generation in napht...

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Veröffentlicht in:Comparative biochemistry and physiology. C, Comparative pharmacology Comparative pharmacology, 1978, Vol.61 (2), p.327-329
Hauptverfasser: Boveris, Alberto, Stoppani, Andrés O.M., Docampo, Roberto, Cruz, Fernando S.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Mitochondria - metabolism
Naphthoquinones - pharmacology
Oxygen
Superoxides
Trypanocidal Agents
Trypanosoma cruzi - drug effects
Trypanosoma cruzi - metabolism
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Zusammenfassung:1. O 2 − production is involved in the toxic action of naphthoquinones against Trypanosoma cruzi as is inferred from the correlation between quinone effect upon growth and the rate of O 2 − release from quinone-treated epimastigotes. 2. Mitochondrial membranes contribute to O 2 − generation in naphthoquinone-treated T. cruzi epimastigotes as is suggested by the correlation between the release of O 2 − from intact cells and the formation of O 2 − from the mitochondrial fraction.
ISSN:0306-4492
DOI:10.1016/0306-4492(78)90063-1