A Sound Rationale Needed for Phase III HIV-1 Vaccine Trials

The need for a human immunodeficiency virus-1 (HIV-1) vaccine is unquestioned and Burton et al assert their strong support for its development as the highest AIDS research priority. However, they express some concern about the wisdom of the US government's sponsoring a recently initiated phase...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-01, Vol.303 (5656), p.316-316
Hauptverfasser:	Burton, Dennis R., Desrosiers, Ronald C., Doms, Robert W., Feinberg, Mark B., Gallo, Robert C., Hahn, Beatrice, Hoxie, James A., Hunter, Eric, Korber, Bette, Landay, Alan, Lederman, Michael M., Lieberman, Judy, McCune, Joseph M., Moore, John P., Nathanson, Neal, Picker, Louis, Richman, Douglas, Rinaldo, Charles, Stevenson, Mario, Watkins, David I., Wolinsky, Steven M., Zack, Jerome A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome (AIDS) AIDS AIDS vaccines Biological and medical sciences Clinical trials Experimentation Feedback (Response) HIV 1 Human immunodeficiency virus 1 Human viral diseases Infections Infectious diseases Medical sciences Opinions Policy Forum Research universities Trials Vaccination Vaccines Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Virology
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Beschreibung
Zusammenfassung:	The need for a human immunodeficiency virus-1 (HIV-1) vaccine is unquestioned and Burton et al assert their strong support for its development as the highest AIDS research priority. However, they express some concern about the wisdom of the US government's sponsoring a recently initiated phase III trial in Thailand of a vaccine made from the live-replicating canarypox vector ALVAC with a boost of monomeric gp120.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1094620