Selective Transmission of Human Immunodeficiency Virus Type-1 Variants from Mothers to Infants

Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother pred...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1992-02, Vol.255 (5048), p.1134-1137
Hauptverfasser:	Wolinsky, Steven M., Wike, Carla M., Bette T. M. Korber, Hutto, Cecelia, Parks, Wade P., Rosenblum, Lisa L., Kunstman, Kevin J., Furtado, Manohar R., Muñoz, José L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome (AIDS) Acquired Immunodeficiency Syndrome - congenital Acquired Immunodeficiency Syndrome - microbiology Acquired Immunodeficiency Syndrome - transmission AIDS AIDS/HIV Amino Acid Sequence Amino acid sequencing Amino acids Analysis Babies Base Sequence Biological and medical sciences Coding Disease transmission Female Fundamental and applied biological sciences. Psychology Genetics Genotype Genotypes Glycosylation HIV HIV (Viruses) HIV Antigens - genetics HIV Envelope Protein gp120 - genetics HIV Envelope Protein gp120 - immunology HIV infection HIV infections HIV-1 - genetics HIV-1 - immunology Humans Infant Infants Maternal-Fetal Exchange Medical research Microbiology Molecular Sequence Data Mothers Multivariate Analysis Oligodeoxyribonucleotides - chemistry Polymerase Chain Reaction Pregnancy Retroviridae Sampling Selection, Genetic Sequence Alignment Virology Viruses Young Children
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Zusammenfassung:	Multiple human immunodeficiency virus type-1 sequences from the V3 and V4-V5 regions of the envelope gene were analyzed from three mother-infant pairs. The infants' viral sequences were less diverse than those of their mothers. In two pairs, a proviral form infrequently found in the mother predominated in her infant. A conserved N-linked glycosylation site within the V3 region, present in each mother's sequence set, was absent in all of the infants' sequence sets. These findings demonstrate that a minor subset of maternal virus is transmitted to the infant.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1546316