Sodium Current-Induced Release of Calcium from Cardiac Sarcoplasmic Reticulum

The role of sodium-calcium exchange at the sarcolemma in the release of calcium from cardiac sarcoplasmic reticulum was investigated in voltage-clamped, isolated cardiac myocytes. In the absence of calcium entry through voltage-dependent calcium channels, membrane depolarization elicited release of...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1990-04, Vol.248 (4953), p.372-376
Hauptverfasser:	Leblanc, Normand, Hume, Joseph R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Biochemistry Biological and medical sciences Calcium Calcium (Nutrient) Calcium - metabolism Calcium - pharmacology Calcium channels Calcium in the body Calcium, Dietary Carrier Proteins - metabolism Cell physiology Depolarization Electric Conductivity Electric current Electric potential Fundamental and applied biological sciences. Psychology Gallopamil - pharmacology Guinea Pigs Heart Medical research Membrane potential Molecular and cellular biology Muscle contraction Myocardial Contraction Myocardium - metabolism Nisoldipine - pharmacology Physiological aspects Pipettes Sarcolemma Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Sodium Sodium (Nutrient) Sodium - metabolism Sodium channels Sodium Channels - drug effects Sodium Channels - physiology Sodium in the body Sodium-Calcium Exchanger Tetrodotoxin - pharmacology
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