Response of F344 rats to inhalation of subclinical levels of sarin: exploring potential causes of Gulf War illness

Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effe...

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Veröffentlicht in:	Toxicology and industrial health 2001-06, Vol.17 (5-10), p.294-297
Hauptverfasser:	Henderson, Rogene F, Barr, Edward B, Blackwell, Walter B, Clark, Connie R, Conn, Carole A, Kalra, Roma, March, Thomas H, Sopori, Mohan L, Tesfaigzi, Yohannes, Ménache, Margaret G, Mash, Deborah C, Dokladny, Karol, Kozak, Wieslaw, Kozak, Anna, Wachulec, Maceij, Rudolph, Karin, Kluger, Matthew J, Singh, Shashi P, Razani-Boroujerdi, Seddigheh, Langley, Raymond J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Blood Body temperature Brain - drug effects Brain - pathology Brain research Chemical Warfare Agents - adverse effects Cognition Disorders - etiology Disease Models, Animal Heat Immune System - drug effects Inhalation Exposure Memory Memory Disorders - etiology Persian Gulf Syndrome Persian Gulf War Rats Rats, Inbred F344 Receptors, Cholinergic - analysis Receptors, Cholinergic - drug effects Sarin - adverse effects Spleen Toxicology
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Zusammenfassung:	Subclinical, repeated exposures of F344 rats to sarin resulted in brain alterations in densities of chlonergic receptor subtypes that may be associated with memory loss and cognitive dysfunction. The exposures also depressed the immune system. The rat appears to be a good model for studying the effects of subclinical exposure to a nerve gas.
ISSN:	0748-2337 1477-0393
DOI:	10.1191/0748233701th105oa