A Requiem for Chloroquine

A Requiem for Chloroquine

Chloroquine (CQ) has historically been the mainstay of malaria treatment; however, the recent development of widespread CQ resistance in Plasmodium falciparum has contributed significantly to escalating mortality rates in Africa and to the resurgence of malaria as an immediate public health priority...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2002-10, Vol.298 (5591), p.74-75
Hauptverfasser: Hastings, I. M., Bray, P. G., Ward, S. A.
Format: Artikel
Sprache:eng
Schlagworte:
Antimalarials
Artemisinins
Biochemistry
Causes of
Chloroquine
Drug resistance
Drug Therapy
Field Studies
Genetic mutation
Human genetics
Infections
Malaria
Medical genetics
Medical treatment
Narcotics
Parasites
Parasitology
Perspectives
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Beschreibung
Zusammenfassung:Chloroquine (CQ) has historically been the mainstay of malaria treatment; however, the recent development of widespread CQ resistance in Plasmodium falciparum has contributed significantly to escalating mortality rates in Africa and to the resurgence of malaria as an immediate public health priority. Research by Sidhu et al regarding resistance to CQ is discussed.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1077573