Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2002-09, Vol.297 (5588), p.1867-1870
Hauptverfasser:	Munn, David H., Sharma, Madhav D., Lee, Jeffrey R., Jhaver, Kanchan G., Johnson, Theodore S., Keskin, Derin B., Marshall, Brendan, Chandler, Phillip, Antonia, Scott J., Burgess, Russell, Slingluff, Craig L., Mellor, Andrew L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of the immune response. Humoral and cellular immunity Antibodies Antigen presenting cells Antigen-Presenting Cells - enzymology Antigen-Presenting Cells - immunology Antigens, CD - analysis Biological and medical sciences Cell Adhesion Cell Lineage Cell lines Cells, Cultured Cellular biology Cultured cells Data lines Dendritic cells Dendritic Cells - enzymology Dendritic Cells - immunology Down-Regulation Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Fundamental immunology Humans Immune system Immune tolerance Immunobiology Immunological tolerance Indoleamine-Pyrrole 2,3,-Dioxygenase Interferon-gamma - pharmacology Interleukin-10 - pharmacology Interleukin-3 Receptor alpha Subunit Lymph nodes Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphoid Tissue - cytology Lymphoid Tissue - enzymology Macrophages - enzymology Organs and cells involved in the immune response Palatine tonsils Receptors, CCR6 Receptors, Chemokine - analysis Receptors, Interleukin-3 - analysis T lymphocytes T-Lymphocytes - immunology Tryptophan - analogs & derivatives Tryptophan - pharmacology Tryptophan Oxygenase - antagonists & inhibitors Tryptophan Oxygenase - metabolism
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Zusammenfassung:	Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature $CD123^+ DCs$. $IDO^+ DCs$ could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1073514