A PEST-Like Sequence in Listeriolysin O Essential for Listeria monocytogenes Pathogenicity

Establishment and maintenance of an intracellular niche are critical to the success of an intracellular pathogen. Here, the pore-forming protein listeriolysin O (LLO), secreted by Listeria monocytogenes, was shown to contain a PEST-like sequence (P, Pro; E, Glu; S, Ser; T, Thr) that is essential for...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2000-11, Vol.290 (5493), p.992-995
Hauptverfasser:	Decatur, Amy L., Portnoy, Daniel A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Sequence Analysis Animals Bacteria Bacterial Toxins - chemistry Bacteriology Biological and medical sciences Cell Line Cell research Cells Cellular biology Cytological research cytolysins Cytosol Cytosol - metabolism DNA Fundamental and applied biological sciences. Psychology HCT116 cells Heat-Shock Proteins - chemistry Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Heat-Shock Proteins - toxicity Hemolysin Proteins Infections L-Lactate Dehydrogenase - metabolism Listeria Listeria monocytogenes Listeria monocytogenes - genetics Listeria monocytogenes - metabolism Listeria monocytogenes - pathogenicity listeriolysin O Listeriosis - microbiology Macrophages Macrophages - microbiology Mice Mice, Inbred BALB C Microbiology Molecular Sequence Data Mutation Pathogenic microorganisms Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Pathogens perfringolysin O PEST protein Pests Phagosomes - microbiology Phosphorylation Polymerase chain reaction Proteins Sequence Deletion Toxicity Virulence
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