Stimulation of human granulocyte elastase by platelet factor 4 and heparin
Highly purified platelet factor 4 (PF 4) was found to be a potent stimulator of human granulocyte elastase activity against native elastin and solubilized α elastin. Heparin neutralized this stimulation of elastolysis by PF 4, but independently stimulated granulocyte elastase activity. Chondroitin s...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1978-12, Vol.85 (3), p.1113-1118 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 85 |
| creator | Lonky, Stewart A. Marsh, James Wohl, Herbert |
| description | Highly purified platelet factor 4 (PF
4) was found to be a potent stimulator of human granulocyte elastase activity against native elastin and solubilized α elastin. Heparin neutralized this stimulation of elastolysis by PF
4, but independently stimulated granulocyte elastase activity. Chondroitin sulfate, a constituent of the PF
4 carrier molecule, also stimulated granulocyte elastase activity. The stimulation of granulocyte elastase by PF
4 occurs at known serum concentrations of PF
4. |
| doi_str_mv | 10.1016/0006-291X(78)90657-5 |
| format | Article |
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4) was found to be a potent stimulator of human granulocyte elastase activity against native elastin and solubilized α elastin. Heparin neutralized this stimulation of elastolysis by PF
4, but independently stimulated granulocyte elastase activity. Chondroitin sulfate, a constituent of the PF
4 carrier molecule, also stimulated granulocyte elastase activity. The stimulation of granulocyte elastase by PF
4 occurs at known serum concentrations of PF
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4) was found to be a potent stimulator of human granulocyte elastase activity against native elastin and solubilized α elastin. Heparin neutralized this stimulation of elastolysis by PF
4, but independently stimulated granulocyte elastase activity. Chondroitin sulfate, a constituent of the PF
4 carrier molecule, also stimulated granulocyte elastase activity. The stimulation of granulocyte elastase by PF
4 occurs at known serum concentrations of PF
4.</description><subject>Blood Coagulation Factors - pharmacology</subject><subject>Enzyme Activation</subject><subject>Granulocytes - enzymology</subject><subject>Heparin - pharmacology</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Pancreatic Elastase - blood</subject><subject>Platelet Factor 4 - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDtPwzAUhS3EqxT-QQdPCIbAdZzE8YKEKp6qxABIbJbj3FCjPIrtIPXfk5KqI9MdzneOdD9CZgyuGLDsGgCyKJbs40LklxKyVETpHpkwkBDFDJJ9Mtkhx-TE-y8AxpJMHpFDwTOZ8gl5fg226WsdbNfSrqLLvtEt_XS67evOrANSrLUP2iMt1nQ1gFhjoJU2oXM0obot6RJX2tn2lBxUuvZ4tr1T8n5_9zZ_jBYvD0_z20VkeJqFKM-1ASFlKZIK4qyQXBrOi7xAoWWZx2BSznOmY825AZlIzGMOCa8MpoYJw6fkfNxdue67Rx9UY73ButYtdr1XIuEcBI8HMBlB4zrvHVZq5Wyj3VoxUBuDaqNHbfQokas_gyodarPtfl80WO5Ko7IhvhljHH78seiUNxZbg6V1aIIqO_v__i_NjH94</recordid><startdate>19781214</startdate><enddate>19781214</enddate><creator>Lonky, Stewart A.</creator><creator>Marsh, James</creator><creator>Wohl, Herbert</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19781214</creationdate><title>Stimulation of human granulocyte elastase by platelet factor 4 and heparin</title><author>Lonky, Stewart A. ; Marsh, James ; Wohl, Herbert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-88ac0799d74f026b939c33b8be7a9d820c53381a2a33c0949e823043fce5c17c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Blood Coagulation Factors - pharmacology</topic><topic>Enzyme Activation</topic><topic>Granulocytes - enzymology</topic><topic>Heparin - pharmacology</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Pancreatic Elastase - blood</topic><topic>Platelet Factor 4 - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lonky, Stewart A.</creatorcontrib><creatorcontrib>Marsh, James</creatorcontrib><creatorcontrib>Wohl, Herbert</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lonky, Stewart A.</au><au>Marsh, James</au><au>Wohl, Herbert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stimulation of human granulocyte elastase by platelet factor 4 and heparin</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1978-12-14</date><risdate>1978</risdate><volume>85</volume><issue>3</issue><spage>1113</spage><epage>1118</epage><pages>1113-1118</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Highly purified platelet factor 4 (PF
4) was found to be a potent stimulator of human granulocyte elastase activity against native elastin and solubilized α elastin. Heparin neutralized this stimulation of elastolysis by PF
4, but independently stimulated granulocyte elastase activity. Chondroitin sulfate, a constituent of the PF
4 carrier molecule, also stimulated granulocyte elastase activity. The stimulation of granulocyte elastase by PF
4 occurs at known serum concentrations of PF
4.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>736953</pmid><doi>10.1016/0006-291X(78)90657-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biochemical and biophysical research communications, 1978-12, Vol.85 (3), p.1113-1118 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74330732 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Blood Coagulation Factors - pharmacology Enzyme Activation Granulocytes - enzymology Heparin - pharmacology Humans Kinetics Pancreatic Elastase - blood Platelet Factor 4 - pharmacology |
| title | Stimulation of human granulocyte elastase by platelet factor 4 and heparin |
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