Stimulation of human granulocyte elastase by platelet factor 4 and heparin

Stimulation of human granulocyte elastase by platelet factor 4 and heparin

Highly purified platelet factor 4 (PF 4) was found to be a potent stimulator of human granulocyte elastase activity against native elastin and solubilized α elastin. Heparin neutralized this stimulation of elastolysis by PF 4, but independently stimulated granulocyte elastase activity. Chondroitin s...

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Veröffentlicht in:Biochemical and biophysical research communications 1978-12, Vol.85 (3), p.1113-1118
Hauptverfasser: Lonky, Stewart A., Marsh, James, Wohl, Herbert
Format: Artikel
Sprache:eng
Schlagworte:
Blood Coagulation Factors - pharmacology
Enzyme Activation
Granulocytes - enzymology
Heparin - pharmacology
Humans
Kinetics
Pancreatic Elastase - blood
Platelet Factor 4 - pharmacology
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Zusammenfassung:Highly purified platelet factor 4 (PF 4) was found to be a potent stimulator of human granulocyte elastase activity against native elastin and solubilized α elastin. Heparin neutralized this stimulation of elastolysis by PF 4, but independently stimulated granulocyte elastase activity. Chondroitin sulfate, a constituent of the PF 4 carrier molecule, also stimulated granulocyte elastase activity. The stimulation of granulocyte elastase by PF 4 occurs at known serum concentrations of PF 4.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(78)90657-5