Meiotic arrest in the mouse follicle maintained by a G(s) protein in the oocyte

Meiotic arrest in the mouse follicle maintained by a G(s) protein in the oocyte

The mammalian ovarian follicle consists of a multilayered complex of somatic cells that surround the oocyte. Mehlmann, Jones, and Jaffe show that meiotic arrest can be released in mice by microinjecting the oocyte within the follicle with an antibody that inhibits the stimulatory heterotrimeric GTP-...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2002-08, Vol.297 (5585), p.1343-1345
Hauptverfasser: Mehlmann, Lisa M, Jones, Teresa L Z, Jaffe, Laurinda A
Format: Artikel
Sprache:eng
Schlagworte:
Cellular biology
Proteins
Reproductive system
Rodents
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Zusammenfassung:The mammalian ovarian follicle consists of a multilayered complex of somatic cells that surround the oocyte. Mehlmann, Jones, and Jaffe show that meiotic arrest can be released in mice by microinjecting the oocyte within the follicle with an antibody that inhibits the stimulatory heterotrimeric GTP-binding protein Gs.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1073978