Mitochondria and Apoptosis

A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1998-08, Vol.281 (5381), p.1309-1312
Hauptverfasser:	Green, Douglas R., Reed, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy & physiology Animal cells Animals Apoptosis Cell death Cell growth Cell organelles Cell research Cells Cellular biology Cysteine Endopeptidases - metabolism Cytochrome c Group - metabolism Cytological research Deoxyribonucleic acid DNA Electron Transport Electrons Humans Intracellular Membranes - metabolism Ion Channels - metabolism Logical Thinking Membrane Potentials Metabolism Mitochondria Mitochondria - metabolism Organelles Oxidation-Reduction Oxygen P branes Permeability Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive oxygen species Reviews Swelling
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Beschreibung
Zusammenfassung:	A variety of key events in apoptosis focus on mitochondria, including the release of caspase activators (such as cytochrome c), changes in electron transport, loss of mitochondrial transmembrane potential, altered cellular oxidation-reduction, and participation of pro- and antiapoptotic Bcl-2 family proteins. The different signals that converge on mitochondria to trigger or inhibit these events and their downstream effects delineate several major pathways in physiological cell death.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.281.5381.1309