Mobile Elements: Drivers of Genome Evolution

Mobile elements within genomes have driven genome evolution in diverse ways. Particularly in plants and mammals, retrotransposons have accumulated to constitute a large fraction of the genome and have shaped both genes and the entire genome. Although the host can often control their numbers, massive...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-03, Vol.303 (5664), p.1626-1632
1. Verfasser:	Kazazian, Haig H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alu Elements Animals Biological and medical sciences Biological evolution DNA DNA Methylation DNA Transposable Elements Evolution Evolution, Molecular Fundamental and applied biological sciences. Psychology Genes Genetic transposition Genetics of eukaryotes. Biological and molecular evolution Genome Genome, Human Genomes Genomics History Humans Long Interspersed Nucleotide Elements Mammals Physiological aspects Recombination, Genetic Reprography Retroelements Retrotransposons Reverse transcription Review RNA RNA, Small Interfering Skilled Workers Terminal Repeat Sequences Transposons
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Beschreibung
Zusammenfassung:	Mobile elements within genomes have driven genome evolution in diverse ways. Particularly in plants and mammals, retrotransposons have accumulated to constitute a large fraction of the genome and have shaped both genes and the entire genome. Although the host can often control their numbers, massive expansions of retrotransposons have been tolerated during evolution. Now mobile elements are becoming useful tools for learning more about genome evolution and gene function.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1089670