Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens

Garsin et al have studied the mechanisms of aging and immune function in Caenorhabditis elegans. They show that the mechanisms that govern these two processes may be interrelated.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-06, Vol.300 (5627), p.1921-1921
Hauptverfasser:	Garsin, Danielle A., Villanueva, Jacinto M., Begun, Jakob, Kim, Dennis H., Sifri, Costi D., Calderwood, Stephen B., Ruvkun, Gary, Ausubel, Frederick M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging (Biology) Alleles Animals Bacteria Bacterial infections Biological and medical sciences Brevia Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - immunology Caenorhabditis elegans - microbiology Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - physiology Critical Reading Enterococcus faecalis - pathogenicity Enterococcus faecalis - physiology Escherichia coli - pathogenicity Escherichia coli - physiology Fellowships Forkhead Transcription Factors Fundamental and applied biological sciences. Psychology Immunology Longevity Microbiology Molecular and cellular biology Molecular Biology Mutation Nematode eggs Nematodes Pathogens Phenotype Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - physiology Physiological aspects Receptor, Insulin - genetics Receptor, Insulin - physiology Staphylococcus aureus - pathogenicity Staphylococcus aureus - physiology Transcription Factors - genetics Transcription Factors - physiology
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Beschreibung
Zusammenfassung:	Garsin et al have studied the mechanisms of aging and immune function in Caenorhabditis elegans. They show that the mechanisms that govern these two processes may be interrelated.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1080147