Laminar flows: Subcellular positioning of small molecules

Laminar flows: Subcellular positioning of small molecules

Localized perturbation of processes that take place inside the living cell depends on molecular and spatial discrimination on a micrometre scale. Here we report the use of multiple laminar streams in a microfluidic channel to deliver membrane-permeable molecules to selected subcellular microdomains....

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Nature (London) 2001-06, Vol.411 (6841), p.1016-1016
Hauptverfasser: Takayama, Shuichi, Ostuni, Emanuele, LeDuc, Philip, Naruse, Keiji, Ingber, Donald E, Whitesides, George M
Format: Artikel
Sprache:eng
Schlagworte:
Localization
Metabolism
Mitochondria
Streams
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Localized perturbation of processes that take place inside the living cell depends on molecular and spatial discrimination on a micrometre scale. Here we report the use of multiple laminar streams in a microfluidic channel to deliver membrane-permeable molecules to selected subcellular microdomains. This technique opens up avenues for non-invasively visualizing, probing and manipulating the cellular metabolic and structural machinery.
ISSN:0028-0836
1476-4687
DOI:10.1038/35082637