Harnessing the Power of the Genome in the Search for New Antibiotics

Over the past 40 years, the search for new antibiotics has been largely restricted to well-known compound classes active against a standard set of drug targets. Although many effective compounds have been discovered, insufficient chemical variability has been generated to prevent a serious escalatio...

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Veröffentlicht in:Science (American Association for the Advancement of Science) 2000-03, Vol.287 (5460), p.1973-1976
Hauptverfasser: Rosamond, John, Allsop, Aileen
Format: Artikel
Sprache:eng
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Zusammenfassung:Over the past 40 years, the search for new antibiotics has been largely restricted to well-known compound classes active against a standard set of drug targets. Although many effective compounds have been discovered, insufficient chemical variability has been generated to prevent a serious escalation in clinical resistance. Recent advances in genomics have provided an opportunity to expand the range of potential drug targets and have facilitated a fundamental shift from direct antimicrobial screening programs toward rational target-based strategies. The application of genome-based technologies such as expression profiling and proteomics will lead to further changes in the drug discovery paradigm by combining the strengths and advantages of both screening strategies in a single program.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.287.5460.1973