Histones Face the FACT

Svejstrup discusses the results of three studies on histones that raise several important issues including the Belotserkovskaya study, which suggests that FACT helps to remove only one of the two histone dimmers during RNAPII transcription through a nucleosome core particle. He stresses the need for future studies, which will yield insights into the molecular details of nucleosome displacement and reassembly during transcription.