hCds-1 mediated phosphorylation of BRCA1 regulates the DNA damage response

Mutations in the BRCA1 (ref. 1) tumour suppressor gene are found in almost all of the families with inherited breast and ovarian cancers and about half of the families with only breast cancer. Although the biochemical function of BRCA1 is not well understood, it is important for DNA damage repair an...

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Veröffentlicht in:	Nature (London) 2000-03, Vol.404 (6774), p.201-204
Hauptverfasser:	Jong-Soo, Lee, Collins, Kimberly M, Brown, Alexandra L, Chang-Hun, Lee, Chung, Jay H
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Deoxyribonucleic acid DNA Genetics Irradiation Mutation Tumors Yeasts
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Mutations in the BRCA1 (ref. 1) tumour suppressor gene are found in almost all of the families with inherited breast and ovarian cancers and about half of the families with only breast cancer. Although the biochemical function of BRCA1 is not well understood, it is important for DNA damage repair and cell-cycle checkpoint.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/35004614