Healthy Animals with Extreme Longevity

In the nematode Caenorhabditis elegans, mutations that inhibit insulin/IGF-1 (insulin-like growth factor 1) signaling, such as daf-2 insulin/IGF-1 receptor mutations, can double their life-span of the animal. Removing the germ-line precursor cells also extends lifespan by approximately 60 percent. R...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2003-10, Vol.302 (5645), p.611-611
Hauptverfasser:	Arantes-Oliveira, Nuno, Berman, Jennifer R., Kenyon, Cynthia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteria Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Biophysics Brevia Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - physiology Fundamental and applied biological sciences. Psychology Genes, Helminth Genetic aspects Genetic mutation Genetics Germ cells Gonads Gonads - physiology Insulin Invertebrates Longevity Movement Mutation Nemathelminthia. Plathelmintha Physiological aspects Physiology. Development Receptor, Insulin - genetics Receptor, Insulin - physiology RNA Interference
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	In the nematode Caenorhabditis elegans, mutations that inhibit insulin/IGF-1 (insulin-like growth factor 1) signaling, such as daf-2 insulin/IGF-1 receptor mutations, can double their life-span of the animal. Removing the germ-line precursor cells also extends lifespan by approximately 60 percent. Removal of the germ-line or the entire reproductive system of daf-2 mutants can further extend life-span: these animals can live four times as long as normal.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1089169