High Frequency of Mutations of the PIK3CA Gene in Human Cancers
Samuels et al discuss the high frequency of mutations of phosphatidylinositol 3-kinases (PI3Ks) gene in human cancers. The PI3Ks are lipid kinases that regulate signaling pathways that are important for neoplasia, including cell proliferation, adhesion, survival and motility.
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2004-04, Vol.304 (5670), p.554-554 |
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| creator | Samuels, Yardena Wang, Zhenghe Bardelli, Alberto Silliman, Natalie Ptak, Janine Szabo, Steve Yan, Hai Gazdar, Adi Powell, Steven M. Riggins, Gregory J. James K. V. Willson Markowitz, Sanford Kinzler, Kenneth W. Vogelstein, Bert Velculescu, Victor E. |
| description | Samuels et al discuss the high frequency of mutations of phosphatidylinositol 3-kinases (PI3Ks) gene in human cancers. The PI3Ks are lipid kinases that regulate signaling pathways that are important for neoplasia, including cell proliferation, adhesion, survival and motility. |
| doi_str_mv | 10.1126/science.1096502 |
| format | Article |
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| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2004-04, Vol.304 (5670), p.554-554 |
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| source | Jstor Complete Legacy; MEDLINE; Science Magazine |
| subjects | Biological and medical sciences Breast Neoplasms - genetics Brevia Cancer Carcinogenesis, carcinogens and anticarcinogens Catalytic Domain Class I Phosphatidylinositol 3-Kinases Coding Colorectal Neoplasms - genetics General aspects Genes Genetic aspects Genetic mutation Glioblastoma - genetics Humans Lipids Lung Neoplasms - genetics Medical sciences Molecular Biology Mutation Neoplasms - genetics Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Research universities Scholarship Funds Sequence Analysis, DNA Stomach Neoplasms - genetics Tumors Tumours Virtual universities |
| title | High Frequency of Mutations of the PIK3CA Gene in Human Cancers |
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