High Frequency of Mutations of the PIK3CA Gene in Human Cancers

Samuels et al discuss the high frequency of mutations of phosphatidylinositol 3-kinases (PI3Ks) gene in human cancers. The PI3Ks are lipid kinases that regulate signaling pathways that are important for neoplasia, including cell proliferation, adhesion, survival and motility.

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Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-04, Vol.304 (5670), p.554-554
Hauptverfasser:	Samuels, Yardena, Wang, Zhenghe, Bardelli, Alberto, Silliman, Natalie, Ptak, Janine, Szabo, Steve, Yan, Hai, Gazdar, Adi, Powell, Steven M., Riggins, Gregory J., James K. V. Willson, Markowitz, Sanford, Kinzler, Kenneth W., Vogelstein, Bert, Velculescu, Victor E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - genetics Brevia Cancer Carcinogenesis, carcinogens and anticarcinogens Catalytic Domain Class I Phosphatidylinositol 3-Kinases Coding Colorectal Neoplasms - genetics General aspects Genes Genetic aspects Genetic mutation Glioblastoma - genetics Humans Lipids Lung Neoplasms - genetics Medical sciences Molecular Biology Mutation Neoplasms - genetics Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Research universities Scholarship Funds Sequence Analysis, DNA Stomach Neoplasms - genetics Tumors Tumours Virtual universities
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Beschreibung
Zusammenfassung:	Samuels et al discuss the high frequency of mutations of phosphatidylinositol 3-kinases (PI3Ks) gene in human cancers. The PI3Ks are lipid kinases that regulate signaling pathways that are important for neoplasia, including cell proliferation, adhesion, survival and motility.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1096502