Adsorption of human IgG on to poly(N-isopropylacrylamide)-based polymer particles
Thermosensitive poly(N-isopropylacrylamide)-based polymer particles were synthesised, and screened for the adsorption of human immunoglobulin G (hIgG). At pH 9 the adsorption on microgel particles was strongly affected by temperature, approximately 40 mg hIgG/g support (90% of initial hIgG) being ad...
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| Veröffentlicht in: | Biotechnology letters 2006-12, Vol.28 (24), p.2019-2025 |
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| container_issue | 24 |
| container_start_page | 2019 |
| container_title | Biotechnology letters |
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| creator | Silva, Claudia S. O Baptista, Ricardo P Santos, Andrea M Martinho, José M. G Cabral, Joaquim M. S Taipa, M. Ângela |
| description | Thermosensitive poly(N-isopropylacrylamide)-based polymer particles were synthesised, and screened for the adsorption of human immunoglobulin G (hIgG). At pH 9 the adsorption on microgel particles was strongly affected by temperature, approximately 40 mg hIgG/g support (90% of initial hIgG) being adsorbed at 40°C but only 10% of initial hIgG at 25°C. At pH 5 the maximum adsorbed amount (20 mg hIgG/g support) was similar for both temperatures. The adsorption of hIgG on to charged poly(methyl methacrylate)/poly(N-isopropylacrylamide) core-shell latexes was negligible (5-10 mg hIgG/g support) at the same temperature and pH conditions. The lower adsorption of hIgG onto the core-shell particles is explained by steric interactions due to the small size of the shell. |
| doi_str_mv | 10.1007/s10529-006-9188-2 |
| format | Article |
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O ; Baptista, Ricardo P ; Santos, Andrea M ; Martinho, José M. G ; Cabral, Joaquim M. S ; Taipa, M. Ângela</creator><creatorcontrib>Silva, Claudia S. O ; Baptista, Ricardo P ; Santos, Andrea M ; Martinho, José M. G ; Cabral, Joaquim M. S ; Taipa, M. Ângela</creatorcontrib><description>Thermosensitive poly(N-isopropylacrylamide)-based polymer particles were synthesised, and screened for the adsorption of human immunoglobulin G (hIgG). At pH 9 the adsorption on microgel particles was strongly affected by temperature, approximately 40 mg hIgG/g support (90% of initial hIgG) being adsorbed at 40°C but only 10% of initial hIgG at 25°C. At pH 5 the maximum adsorbed amount (20 mg hIgG/g support) was similar for both temperatures. The adsorption of hIgG on to charged poly(methyl methacrylate)/poly(N-isopropylacrylamide) core-shell latexes was negligible (5-10 mg hIgG/g support) at the same temperature and pH conditions. The lower adsorption of hIgG onto the core-shell particles is explained by steric interactions due to the small size of the shell.</description><identifier>ISSN: 0141-5492</identifier><identifier>EISSN: 1573-6776</identifier><identifier>DOI: 10.1007/s10529-006-9188-2</identifier><identifier>PMID: 17021661</identifier><identifier>CODEN: BILED3</identifier><language>eng</language><publisher>Dordrecht: Dordrecht : Kluwer Academic Publishers</publisher><subject>Acrylamides - pharmacokinetics ; Acrylic Resins ; Adsorption ; Biological and medical sciences ; Biotechnology ; Fundamental and applied biological sciences. Psychology ; Human immunoglobulin G ; Humans ; Hydrogen-Ion Concentration ; Immunoglobulin G - chemistry ; Immunoglobulin G - metabolism ; Nanoparticles - chemistry ; Poly(methyl methacrylate) ; Poly(N-isopropylacrylamide) ; Polymers ; Polymers - chemistry ; Polymers - pharmacokinetics ; Temperature ; Thermosensitive polymers ; Time Factors</subject><ispartof>Biotechnology letters, 2006-12, Vol.28 (24), p.2019-2025</ispartof><rights>2007 INIST-CNRS</rights><rights>Springer Science+Business Media, Inc. 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-861283c64afbb49f0d4c2c25c250fea8d2af38e4d3c2f76ce3580b3ad82badbb3</citedby><cites>FETCH-LOGICAL-c509t-861283c64afbb49f0d4c2c25c250fea8d2af38e4d3c2f76ce3580b3ad82badbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18373815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17021661$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Claudia S. O</creatorcontrib><creatorcontrib>Baptista, Ricardo P</creatorcontrib><creatorcontrib>Santos, Andrea M</creatorcontrib><creatorcontrib>Martinho, José M. G</creatorcontrib><creatorcontrib>Cabral, Joaquim M. S</creatorcontrib><creatorcontrib>Taipa, M. Ângela</creatorcontrib><title>Adsorption of human IgG on to poly(N-isopropylacrylamide)-based polymer particles</title><title>Biotechnology letters</title><addtitle>Biotechnol Lett</addtitle><description>Thermosensitive poly(N-isopropylacrylamide)-based polymer particles were synthesised, and screened for the adsorption of human immunoglobulin G (hIgG). At pH 9 the adsorption on microgel particles was strongly affected by temperature, approximately 40 mg hIgG/g support (90% of initial hIgG) being adsorbed at 40°C but only 10% of initial hIgG at 25°C. At pH 5 the maximum adsorbed amount (20 mg hIgG/g support) was similar for both temperatures. The adsorption of hIgG on to charged poly(methyl methacrylate)/poly(N-isopropylacrylamide) core-shell latexes was negligible (5-10 mg hIgG/g support) at the same temperature and pH conditions. The lower adsorption of hIgG onto the core-shell particles is explained by steric interactions due to the small size of the shell.</description><subject>Acrylamides - pharmacokinetics</subject><subject>Acrylic Resins</subject><subject>Adsorption</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human immunoglobulin G</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Immunoglobulin G - chemistry</subject><subject>Immunoglobulin G - metabolism</subject><subject>Nanoparticles - chemistry</subject><subject>Poly(methyl methacrylate)</subject><subject>Poly(N-isopropylacrylamide)</subject><subject>Polymers</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacokinetics</subject><subject>Temperature</subject><subject>Thermosensitive polymers</subject><subject>Time Factors</subject><issn>0141-5492</issn><issn>1573-6776</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqF0VFr1TAUB_AgDnedfgBftAjqfIiek6RJ-jiGboMxEd1zSNNkdrRNl7QP99ub670w8EEhJAR-OZyTPyGvED4hgPqcEWrWUABJG9Sasidkg7XiVColn5INoEBai4Ydk-c53wNAo0A9I8eogKGUuCHfz7oc07z0capiqH6to52qq7uLqtyXWM1x2J7e0D7HOcV5O1iXyjb2nf9IW5t990eMPlWzTUvvBp9fkKNgh-xfHs4Tcvv1y8_zS3r97eLq_OyauhqahWqJTHMnhQ1tK5oAnXDMsbosCN7qjtnAtRcddywo6TyvNbTcdpq1tmtbfkI-7OuWzh5Wnxcz9tn5YbCTj2s2SnDUwJUs8v0_pdTY1MDYf2FhGhXHAt_-Be_jmqYyrlFcqEYItkO4Ry7FnJMPZk79aNPWIJhdfmafnyn5mV1-ZtfB60PhtR199_jiEFgB7w7AZmeHkOzk-vzoNFdcY13cm70LNhp7l4q5_cEAOSCiLn_MfwNQK6tS</recordid><startdate>20061201</startdate><enddate>20061201</enddate><creator>Silva, Claudia S. 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O</au><au>Baptista, Ricardo P</au><au>Santos, Andrea M</au><au>Martinho, José M. G</au><au>Cabral, Joaquim M. S</au><au>Taipa, M. Ângela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adsorption of human IgG on to poly(N-isopropylacrylamide)-based polymer particles</atitle><jtitle>Biotechnology letters</jtitle><addtitle>Biotechnol Lett</addtitle><date>2006-12-01</date><risdate>2006</risdate><volume>28</volume><issue>24</issue><spage>2019</spage><epage>2025</epage><pages>2019-2025</pages><issn>0141-5492</issn><eissn>1573-6776</eissn><coden>BILED3</coden><abstract>Thermosensitive poly(N-isopropylacrylamide)-based polymer particles were synthesised, and screened for the adsorption of human immunoglobulin G (hIgG). At pH 9 the adsorption on microgel particles was strongly affected by temperature, approximately 40 mg hIgG/g support (90% of initial hIgG) being adsorbed at 40°C but only 10% of initial hIgG at 25°C. At pH 5 the maximum adsorbed amount (20 mg hIgG/g support) was similar for both temperatures. The adsorption of hIgG on to charged poly(methyl methacrylate)/poly(N-isopropylacrylamide) core-shell latexes was negligible (5-10 mg hIgG/g support) at the same temperature and pH conditions. The lower adsorption of hIgG onto the core-shell particles is explained by steric interactions due to the small size of the shell.</abstract><cop>Dordrecht</cop><pub>Dordrecht : Kluwer Academic Publishers</pub><pmid>17021661</pmid><doi>10.1007/s10529-006-9188-2</doi><tpages>7</tpages></addata></record> |
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| issn | 0141-5492 1573-6776 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Acrylamides - pharmacokinetics Acrylic Resins Adsorption Biological and medical sciences Biotechnology Fundamental and applied biological sciences. Psychology Human immunoglobulin G Humans Hydrogen-Ion Concentration Immunoglobulin G - chemistry Immunoglobulin G - metabolism Nanoparticles - chemistry Poly(methyl methacrylate) Poly(N-isopropylacrylamide) Polymers Polymers - chemistry Polymers - pharmacokinetics Temperature Thermosensitive polymers Time Factors |
| title | Adsorption of human IgG on to poly(N-isopropylacrylamide)-based polymer particles |
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