DNA methylation is independent of RNA interference in Neurospora

Freitag et al analyze the DNA of mutants defective in components of the RNAi machinery to determine whether Neurospora relies on RNA silencing to induce DNA methylation. They conclude that RNA silencing is not universally involved in formation and maintenance of heterochromatin and that RNA-mediated...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2004-06, Vol.304 (5679), p.1939-1939
Hauptverfasser:	Freitag, M, Lee, D.W, Kothe, G.O, Pratt, R.J, Aramayo, R, Selker, E.U
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Brevia Deoxyribonucleic acid DNA DNA Methylation DNA methyltransferase DNA, Fungal - metabolism Double stranded RNA Fundamental and applied biological sciences. Psychology Fungal Proteins - metabolism gene expression regulation Gene Silencing Heterochromatin Heterochromatin - metabolism Histone-Lysine N-Methyltransferase - metabolism Methods Methylation methyltransferases Microbiology Molecular Biology mutants Mutation Neurospora Neurospora crassa Neurospora crassa - genetics Neurospora crassa - metabolism Physiological aspects Protein Methyltransferases Ribonucleic acid RNA RNA Interference Techniques used in virology Virology
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Zusammenfassung:	Freitag et al analyze the DNA of mutants defective in components of the RNAi machinery to determine whether Neurospora relies on RNA silencing to induce DNA methylation. They conclude that RNA silencing is not universally involved in formation and maintenance of heterochromatin and that RNA-mediated in plants, is not "a general means of targeting de novo methylation."
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.1099709